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The Insect Voltage-Gated Sodium Channel as Target of Insecticides

Examination of the function, chemistry, and pharmacology of the voltage-gated insect sodium channel (ISC) reveals that the ISC closely resembles its vertebrate counterpart in electrophysiology and ion conductance, primary structure and allocation of all functional domains, and its pharmacological diversity and flexibility exhibited by the occurrence of different allosterically coupled receptor-binding sites for various neurotoxicants. ...

Publisher - Annual Reviews

Subjects - Chemical, Dichlorodiphenyltrichloroethane, DDT; Chemical, Pyrethroids; Insecticide


Citation: Zlotkin E. 1999. The Insect Voltage-Gated Sodium Channel as Target of Insecticides. Ann. Rev. Entomol.; 44:429-455 http://dx.doi.org/10.1146/annurev.ento.44.1.429